關(guān)鍵詞

ChatGPT?干細(xì)胞 線粒體 糖蛋白 基因組學(xué) 吞噬細(xì)胞 單克隆抗體 胰島素 ?

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#今日行業(yè)熱點(diǎn)#

①Nature Biotechnology：Drug discovery companies are customizing ChatGPT: heres how

藥物研發(fā)公司通過定制ChatGPT幫助科學(xué)家與人工智能對話，甚至產(chǎn)生潛在的藥物靶點(diǎn)

DOI :10.1038/s41587-023-01788-7

②Nature子刊：Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy

轉(zhuǎn)錄因子Nkx2-3通過調(diào)節(jié)線粒體吞噬來維持造血干細(xì)胞（HSCs）的自我更新

DOI :10.1038/s41375-023-01907-y

③Journal of Advanced Research：Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression

腫瘤浸潤性肥大細(xì)胞通過IL-33和IL-2軸刺激ICOS+調(diào)節(jié)性T細(xì)胞，促進(jìn)胃癌進(jìn)展

DOI :10.1016/j.jare.2023.04.013

④Frontiers in Immunology：Role of CD147 in the development and diagnosis of hepatocellular carcinoma

綜述：糖蛋白CD147的分子結(jié)構(gòu)及其在調(diào)控肝細(xì)胞癌（HCC）侵襲、轉(zhuǎn)移和血管生成中的作用

DOI :10.3389/fimmu.2023.1149931

⑤Frontiers in Immunology：Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii

對弓形蟲感染小鼠腸道微生物群組成和功能的宏基因組學(xué)研究
DOI :10.3389/fimmu.2023.1156397

⑥Frontiers in Immunology：Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs

綜述：腫瘤相關(guān)巨噬細(xì)胞（TAMs）作為人類和狗癌癥的靶點(diǎn)和預(yù)后改善策略

DOI :10.3389/fimmu.2023.1176807

⑦重組人源化抗PCSK9單克隆抗體用于原發(fā)性高膽固醇血癥和混合型高脂血癥的上市申請獲得受理

⑧國家藥監(jiān)局：以臨床價值為導(dǎo)向，鼓勵放射性藥品研發(fā)申報

⑨全球首款口服胰島素制劑重組人胰島素腸溶膠囊（ORMD-0801）在華申報上市，適用于口服降糖藥效果不佳的2型糖尿病

⑩創(chuàng)新類固醇藥物Vamorolone用于杜氏肌營養(yǎng)不良（DMD）的臨床試驗(yàn)申請獲CDE受理

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