Motixafortide/BKT140 (4-fluorobenzoyl)，是CXCR4的最佳拮抗劑
2022-12-16 23:01 作者:youngshe-Leslie | 我要投稿
Motixafortide ?(Synonyms: BKT140 (4-fluorobenzoyl); BL-8040; TF14016)
分子: 2159.52
分子式: C97H144FN33O19S2
CAS 番號(hào): 664334-36-5
Motixafortide（以前稱為BL-8040/BKT140）是CXCR4趨化因子受體的一種新型選擇性抑制劑。CXCR4是一種經(jīng)過充分驗(yàn)證的有效成分，它參與造血干細(xì)胞、免疫細(xì)胞和癌細(xì)胞從骨髓和淋巴結(jié)到外周血的動(dòng)員和運(yùn)輸。Motixafortide的獨(dú)特特性，包括高親和力、長(zhǎng)受體占有率和反向激動(dòng)劑活性，使其成為CXCR4的最佳拮抗劑。
Motixafortide
?(BKT140) displays selective toxicity toward AmL and MM cells.
Treatment ?with Motixafortide (BKT140) can overcome IL-6 dependent
proliferation ?and survival of ARH77 MM cells. Motixafortide (BKT140)
specifically ?triggers CXCR4-dependent cell death in leukemia and MM
cells. ?Motixafortide (BKT140) stimulates apoptotic cell death in
leukemia and ?MM cells.
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