簡(jiǎn)介

皮膚老化的最主要特征是臉部皺紋的增加，這既是人類基因預(yù)選安排的程序，又存在環(huán)境的加速因素，比如臉部皮膚不斷受到壓迫（如睡覺(jué)時(shí)），經(jīng)常性的臉部表情導(dǎo)致的肌肉收縮運(yùn)動(dòng)等等。從生理學(xué)上講，皮膚的衰老表現(xiàn)在膠原蛋白和彈性蛋白的減少，皮膚油脂的無(wú)規(guī)則排列。近年來(lái)已有文獻(xiàn)報(bào)道，為了有效避免這些情況產(chǎn)生可以通過(guò)以下兩種方法：抑制SNARE組合體的合成；抑制兒茶酚胺的釋放。

乙?；穗?3為阿基瑞林的延長(zhǎng)類似物，為模仿 SNAP- 25 蛋白的 N 端并由八個(gè)氨基酸組成的寡肽。臨床實(shí)驗(yàn)證實(shí)八勝肽是基于人體皮膚生化機(jī)制而科學(xué)合理設(shè)計(jì)的抗皺多肽活性原料, 現(xiàn)已成為風(fēng)靡世界的用于抗皺的化妝品原料,其功效可以與 A 型肉毒素媲美, 但是又避開(kāi)了肉毒素的必須注射和使用成本高昂的缺點(diǎn)。

Acetyl group octopeptide-3 is an elongated analogue of Akirelin, an oligopeptide consisting of eight amino acids that mimics the N-terminal of SNAP-25 protein. Clinical experiments have confirmed that octapeptide is a scientifically and reasonably designed anti wrinkle peptide active raw material based on the biochemical mechanism of human skin. It has become a popular cosmetic raw material for anti wrinkle use worldwide. Its efficacy can be comparable to that of type A botulinum toxin, but it avoids the drawbacks of botulinum toxin's mandatory injection and high cost of use.

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INCI??????乙?；穗?3

參考 ?????SNAP-8

英文??????Acetyl Octapeptide-3

CAS 號(hào) ??868844-74-0

分子量????1075.16

分子式 ???C41H70N16O16S

多肽序列??Ac-EEMQRRAD-NH2

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機(jī)理

肌肉在接受到神經(jīng)遞質(zhì)時(shí)會(huì)發(fā)生收縮（摘自A.FerrerMontieletal，TheJournalofBiologicalChemistry，1997，272，2634-2638）。神經(jīng)遞質(zhì)是在神經(jīng)元胞體中合成的，并貯存在突觸小泡內(nèi)，當(dāng)受到外界刺激時(shí)，一種對(duì)鈣有依賴性的胞外分泌物（稱為SNARE蛋白質(zhì)組合體）使突觸小泡釋放出神經(jīng)遞質(zhì)，并經(jīng)突觸縫隙到達(dá)突觸后膜，與相應(yīng)的受體結(jié)合而發(fā)生作用。SNARE是由三種蛋白質(zhì)VAMP、Syntaxin和SNAP-25結(jié)合而成的。

Muscles contract when they receive neurotransmitters (excerpted from A. FerrerMontieltal, The Journal of Biological Chemistry, 19972722634-2638). Neurotransmitters are synthesized in the neuronal cell body and stored in the Synaptic vesicle. When stimulated by the outside world, a calcium dependent extracellular secretion (called SNARE protein complex) makes the Synaptic vesicle release neurotransmitters, and then reach the postsynaptic membrane through the synaptic gap to interact with the corresponding receptors. SNARE is composed of three proteins: VAMP, Syntaxin, and SNAP-25.