恩弗利單抗，Envafolimab，CAS: 2102192-68-5，AntibodySystem Laboratories

貨號：DHJ70104

產(chǎn)品鏈接：http://www.atagenix.com/product_detail-75183.html

別名：KN-035, CAS: 2102192-68-5

簡介：

恩弗利單抗? Envafolimab (ASC 22; KN 035) 是人源化的單域抗 PD-L1 抗體的重組蛋白。Envafolimab 是由抗 PD-L1 結(jié)構(gòu)域與人 IgG1 抗體的 Fc 片段融合而成。Envafolimab 阻斷 PD-L1 和 PD-1 之間的相互作用，IC50 值為 5.25?nM。Envafolimab 具有研究實體瘤的潛力。

貨號：DHJ70104

產(chǎn)品品牌：Antibodysystem

通用名；Envafolimab

純度：>95% by SDS-PAGE.

濃度：1mg/ml

Formulationicon：0.01M PBS, pH 7.4.

內(nèi)毒素：Please contact with the lab for this information.

別名：KN-035

靶點；物種：Human CD274/PD-L1/B7-H1

種類：Chimeric

受體鑒定：(VH-CH2-CH3)2

CAS：2102192-68-5

存儲條件：

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

參考文獻(xiàn)：

Envafolimab: First Approval. PMID: 35122636

Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors. PMID: 34154614

First-in-Human Phase I Study of Envafolimab, a Novel Subcutaneous Single-Domain Anti-PD-L1 Antibody, in Patients with Advanced Solid Tumors. PMID: 33973293

Envafolimab - first PD-1/PD-L1 antibody to be administered by subcutaneous injection for microsatellite instability-high or deficient mismatch repair advanced solid tumors. PMID: 36124972

Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors. PMID: 35932387

Envafolimab combined with chemotherapy in the treatment of combined small cell lung cancer: A case report. PMID: 36874434

Case report: A case of complete clinical response in a patient experiencing high microsatellite instability unresectable colon cancer being treated with a PD-L1 inhibitor after interstitial pneumonia. PMID: 36998453

Design, synthesis, and preclinical evaluation of a novel bifunctional macrocyclic chelator for theranostics of cancers. PMID: 35347438

Residue-specific binding mechanisms of PD-L1 to its monoclonal antibodies by computational alanine scanning. PMID: 34259259

Noninvasive Imaging of Tumor PD-L1 Expression Using [99mTc]Tc-Labeled KN035 with SPECT/CT. PMID: 36541699