This N-terminal tripeptide of IGF-I facilitated the in vitro release of acetylcholine with a several hundredfold higher potency (10?1? - 10?? M) than intact IGF-I (4 · 10?? M), whereas truncated IGF-I lacking the tripeptide GPE, did not show any significant effect. This raises the possibility that GPE may be the active site of IGF-I. - Although the precise mode of action of GPE is still unknown, another study suggests that local administration of GPE is neuroprotective after brain HI injury via glial cells. In addition, systemic administration of GPE showed a more widespread neuroprotective effect. Therefore, GPE may represent a complementary pathway for central and systemic IGF-1's antiapoptotic effects.這種IGF-I的n端三肽促進乙酰膽堿的體外釋放，藥效(1011?- 10￣M)比完整的IGF-I(4·10￣M)高數(shù)百倍，而缺失GPE三肽的截斷型IGF-I并沒有表現(xiàn)出明顯的效果。這就提出了GPE可能是IGF-I的活性位點的可能性。-雖然GPE的確切作用模式尚不清楚，但另一項研究表明，局部給藥通過膠質(zhì)細胞對腦HI損傷具有神經(jīng)保護作用。此外，全身給藥GPE表現(xiàn)出更廣泛的神經(jīng)保護作用。因此，GPE可能是中樞和全身IGF-1抗凋亡作用的補充途徑。

編號: 138222
中文名稱: 三肽Gly-Pro-Glu
英文名: Gly-Pro-Glu
CAS號: 32302-76-4
單字母: H2N-GPE-OH
三字母: H2N-Gly-Pro-Glu-COOH
氨基酸個數(shù): 3
分子式: C12H19N3O6
平均分子量: 301.3
精確分子量: 301.13
等電點(PI): 3.85
pH=7.0時的凈電荷數(shù): -1.02
平均親水性: 3
疏水性值: -1.83
來源: 人工化學合成，僅限科學研究使用，不得用于人體。
純度: 95%、98%
鹽體系: 可選TFA、HAc、HCl或其它
生成周期: 2-3周
儲存條件: 負80℃至負20℃
標簽: 三肽 糖尿病

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